Carcinoma of Unknown Primary and the 8th Edition <scp>TNM</scp> Classification for Head and Neck Cancer

Objective In the 8th Edition TNM Classification for Head and Neck Cancer, classification carcinoma of unknown primary (CUP) changed in addition to oropharyngeal carcinomas. The current considers extranodal extension (ENE), determination p16 (surrogate marker human papillomavirus), detection Epstein-Barr virus (EBV). aim this study was investigate influence new on prognosis p16-positive p16-negative CUP impact EBV proof. Methods Clinical pathological data from patients with head neck between 2009 2018 were evaluated. 7th (UICC7) (UICC8) edition Union International Cancer Control staging system applied compared. Results There 97 treated, 26.8% women 73.2% men. average age at initial diagnosis 64.6 years. Of which, 58.8% had a documented history smoking, 37.1% positive p16, 4.1% EBV, 66% ENE. Most stage III/IVa (78.4% according UICC7). According UICC8, p16+ mainly I (86.1%), p16− IVb (56.1%). P16 status (P = .002), ENE .001), nodal category (TNM7, P < UICC .001) (TNM8, significant survival univariate analysis. resulted downstaging syndromes an upstaging syndromes. Conclusion shows lower prognostic significance has improved classification. Level Evidence using 2011 OCEBM 3. Laryngoscope, 131:E2534–E2542, 2021